https://nova.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:42660 Wed 31 Aug 2022 13:09:31 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:43637 Wed 30 Nov 2022 09:37:22 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:43709 Wed 28 Sep 2022 10:15:57 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:36891 Wed 15 Jul 2020 12:45:43 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:41437 Wed 13 Mar 2024 18:29:09 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:9207 Wed 11 Apr 2018 17:20:25 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:3013 Wed 11 Apr 2018 16:44:44 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:25122 Wed 11 Apr 2018 16:05:40 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:27783 Wed 11 Apr 2018 15:24:25 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:4597 Wed 11 Apr 2018 15:22:56 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:26650 Wed 11 Apr 2018 15:18:55 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:4672 Wed 11 Apr 2018 15:17:20 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:22903 Wed 11 Apr 2018 14:44:59 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:9275 Wed 11 Apr 2018 13:58:28 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:20999 p < 0.01) but did not produce significant changes in the dominant hand on any measure (p > 0.05). This effect occurred irrespective of the hemisphere stimulated. Stimulation did not produce significant effects on measures of gross function, grip strength, reaction times, or electrophysiological measures on the EEG data. Conclusion: This study demonstrated that the hemispheres respond differently to anodal stimulation and the response appears to be task specific but not mediated by age.]]> Wed 11 Apr 2018 13:01:16 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:25679 Wed 11 Apr 2018 12:32:11 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:30401 Wed 11 Apr 2018 12:20:27 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:22902 Wed 11 Apr 2018 11:55:45 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:4598 Wed 11 Apr 2018 11:37:35 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:12830 Wed 11 Apr 2018 11:34:49 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:23176 Wed 11 Apr 2018 10:53:16 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:7318 Wed 11 Apr 2018 10:24:39 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:43773 Wed 07 Feb 2024 17:17:37 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:34097 Wed 04 Sep 2019 12:18:51 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:34333 Wed 02 Mar 2022 14:24:45 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:32861 Tue 31 Jul 2018 11:58:49 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:25818 Tue 24 Jan 2017 14:52:42 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:27692 Tue 23 May 2017 10:42:30 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:45497 Tue 19 Mar 2024 15:42:12 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:40837 Tue 19 Jul 2022 10:54:29 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:46325 Tue 15 Nov 2022 12:07:00 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:43171 Tue 13 Sep 2022 16:03:39 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:54222 Tue 13 Feb 2024 12:11:44 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:21499 Tue 10 Nov 2015 11:59:49 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:34711 Tue 03 Sep 2019 18:16:58 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:33546 Tue 03 Sep 2019 18:01:10 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:39950 Thu 30 Jun 2022 14:36:45 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:23043 Thu 18 Aug 2016 14:52:57 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:23042 Thu 18 Aug 2016 14:52:53 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:23038 r) plays a significant role in the grout bulbs generation and development in relation to the soil water characteristics. With the S_r increase from 5 %, the mass of injected grout decreases followed by an increase after a threshold value of about 40%; on the other hand, compaction grouting seems to be dominant at the threshold S_r value, while factures tend to appear at both lower and higher degree of saturation.]]> Thu 18 Aug 2016 14:45:53 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:32274 Thu 17 May 2018 13:51:21 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:43277 Thu 15 Sep 2022 12:09:32 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:50913 Thu 10 Aug 2023 15:24:02 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:55046 Thu 04 Apr 2024 13:58:38 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:36726 ɛ4/ɛ3> ɛ3/ɛ3> ɛ2/ɛ3> ɛ2/ɛ2). The greatest variation in lipids was related to the ɛ2 isoform, where various lysophosphatidylcholines and all phosphatidylethanolamine (PE) subclasses were elevated relative to ɛ3/ɛ3 and ɛ4 carriers. APOE ɛ4 carriers had reduced phosphatidylinositol relative to ɛ3/ɛ3 and ɛ2 carriers. Logistic regression revealed that ɛ2 carriers were at least 4 times higher odds of being in the highest tertile of PE lipid level relative to ɛ3/ɛ3. The elevation in PE and other phospholipids in ɛ2 carriers may indicate the protective effect of ɛ2 is linked to these phospholipids. Additionally, high baseline PE in cognitively normal participants predicted protection against cognitive decline six years later. Our data suggest substantial modulation of plasma lipids by APOE genotype and therefore indicates possible lipid targets and pathomechanisms involved in AD risk.]]> Thu 02 Jul 2020 09:10:42 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:12330 Sat 24 Mar 2018 10:36:50 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:31483 Sat 24 Mar 2018 08:45:13 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:31464 N = 224) showed that negative experiences of family problems and cyber-perpetration predicted low generalized trust. Exploratory Study 2 (N = 196) showed no significant direct relationship, but trust was related to low online privacy concerns and the willingness to self-disclose online was positively related to cyber-victimization and cyber-perpetration. Thus, these studies show mixed evidence and demonstrate that the relationship between cyberbullying and trust might be more complex than assumed. Future longitudinal designs might be illuminating.]]> Sat 24 Mar 2018 08:43:49 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:31367 Sat 24 Mar 2018 08:43:42 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:8806 Sat 24 Mar 2018 08:38:18 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:15311 Sat 24 Mar 2018 08:20:00 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:10312 0.05). In participants without dementia (n=749), neither serum ferritin in 1994/5 or 2003/4 nor change in serum ferritin between these times was related to total CAMCOG or executive function scores, with or without adjustment for gender, age, National Adult reading test, or stroke history (all p> 0.05). No relationships were observed between ferritin and cognition for participants with possible or probable dementia (n=51). All participants identified as HFE C282Y homozygous or with serum ferritin >1,000 ng/ml had normal CAMCOG scores. We conclude abnormal body iron stores (low or high) are unlikely to have clinically significant effects on cognition or dementia risk in community-dwelling older people.]]> Sat 24 Mar 2018 08:12:22 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:11947 Sat 24 Mar 2018 08:09:01 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:19903 Sat 24 Mar 2018 08:03:48 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:19672 Sat 24 Mar 2018 08:01:12 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:21780 Sat 24 Mar 2018 08:00:39 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:20749 Sat 24 Mar 2018 08:00:24 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:20397 Sat 24 Mar 2018 07:58:09 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:20882 -/- mice, a model of hemochromatosis, relative to age- and gender-matched wildtype controls. Classification by functional pathway analysis revealed transcript changes for various genes important in AD. There were decreases of up to 9-fold in transcripts for amyloid-β protein precursor, tau, apolipoprotein E, presenilin 1, and various other γ-secretase components, as well as Notch signaling pathway molecules. This included decreased transcripts for 'hairy and enhancer of split' Hes1 and Hes5, downstream targets of Notch canonical signaling. The reductions in Hes1 and Hes5 transcripts provide evidence that the changes in levels of transcripts for γ-secretase components and Notch signaling genes have functional consequences. The effects appeared relatively specific for AD in that few genes pertaining to other important neurodegenerative diseases, notably Parkinson's disease and Huntington's disease, or to inflammation, oxidative stress, or apoptosis, showed altered transcript levels. The observed effects on AD-related gene transcripts do not appear to be consistent with increased AD risk in HFE hemochromatosis and might, if anything, be predicted to protect against AD to some extent. As Hfe^-/- mice did not have higher brain iron levels than wildtype controls, these studies highlight the need for further research in models of more severe hemochromatosis with brain iron loading.]]> Sat 24 Mar 2018 07:57:56 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:17878 Sat 24 Mar 2018 07:56:13 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:26280 Sat 24 Mar 2018 07:40:12 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:27902 Sat 24 Mar 2018 07:38:00 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:30114 Sat 24 Mar 2018 07:37:56 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:26600 Sat 24 Mar 2018 07:33:59 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:28945 Sat 24 Mar 2018 07:31:25 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:3857 Sat 24 Mar 2018 07:19:50 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:52824 Mon 30 Oct 2023 09:18:14 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:49682 Mon 29 May 2023 10:12:45 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:49681 Mon 29 May 2023 10:05:58 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:46668 Mon 28 Nov 2022 19:00:22 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:25179 Mon 24 Jun 2019 18:45:04 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:47529 Mon 23 Jan 2023 12:23:03 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:46412 3 months. Differences between kinematic variables were determined using one-way repeated measures ANOVA with Bonferroni post-hoc tests. RESULTS: Compared to the desktop (sitting), tablet and laptop use resulted in increased neck flexion (mean difference tablet - 14.42°, 95% CI - 19.88, -8.96, P < 0.001; laptop -7.19°, -12.08, -2.31, P = .020); upper trunk flexion (tablet -14.89°, -20.22, -9.56, P < 0.001; laptop -5.56°, -10.02, -1.09, P = .009) and tablet bilateral shoulder elevation (left 11.01 mm, 2.01, 20.04, P < .016; right 13.08 mm, 3.09, 23.11, P < .006). Conclusions: Tablet and laptop use resulted in greater neck flexion, bilateral shoulder elevation and upper trunk flexion compared to a standard desktop computer, suggesting individuals with chronic neck pain should be mindful of their posture when using these smaller devices. Future research should explore how differences in posture may influence neck pain.]]> Mon 21 Nov 2022 14:12:56 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:41897 2, test for interaction p < 0.0001), and among men (test for interaction p < 0.0001). When the underreporting of Indigenous status on the death certificate was taken into account the relative rate increased to 2.17, 95% CI (2.07, 2.29). Indigenous Australians were also more likely to have their dementia coded as 'unspecified' on their death certificate (Odds Ratio 1.92, 95% CI (1.66, 2.21), p<0.0001), compared to the non-Indigenous group. Conclusion: This epidemiological analysis based on population level mortality data demonstrates the higher dementia-related mortality rate for Indigenous Australians especially at younger ages.]]> Mon 15 Aug 2022 12:23:26 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:30488 Mon 13 Aug 2018 12:55:55 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:49254 Mon 08 May 2023 10:56:30 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:49255 Mon 08 May 2023 10:56:13 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:49232 Mon 08 May 2023 09:53:03 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:39219 HFE p.C282Y variant can cause iron overload and hemochromatosis, mostly in homozygous males. Objective: To estimate p.C282Y associations with brain MRI features plus incident dementia diagnoses during follow-up in a large community cohort. Methods: UK Biobank participants with follow-up hospitalization records (mean 10.5 years). MRI in 206 p.C282Y homozygotes versus 23,349 without variants, including T2* measures (lower values indicating more iron). Results: European ancestry participants included 2,890 p.C282Y homozygotes. Male p.C282Y homozygotes had lower T2* measures in areas including the putamen, thalamus, and hippocampus, compared to no HFE mutations. Incident dementia was more common in p.C282Y homozygous men (Hazard Ratio HR = 1.83; 95% CI 1.23 to 2.72, p = 0.003), as was delirium. There were no associations in homozygote women or in heterozygotes. Conclusion: Studies are needed of whether early iron reduction prevents or slows related brain pathologies in male HFE p.C282Y homozygotes.]]> Fri 27 May 2022 11:37:31 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:48653 Fri 24 Mar 2023 16:04:46 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:35154 Fri 21 Jun 2019 14:59:03 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:35156 Fri 21 Jun 2019 14:59:02 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:23088 Fri 19 Aug 2016 12:48:52 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:46149 40 and Aβ₄₂ concentrations were measured using the ultrasensitive Single Molecule Array (Simoa) assay in 95 cognitively normal elderly individuals, who have all undergone PET to assess brain Aβ deposition. Based on the standard uptake value ratios (SUVR) obtained from PET imaging, using the tracer ¹⁸F-Florbetaben, plasma Aβ was compared between 32 participants assessed to have low brain Aβ load (Aβ–, SUVR <1.35) and 63 assessed to have high brain Aβ load (Aβ+, SUVR ≥1.35). Results: Plasma Aβ₄₂/Aβ₄₀ ratios were lower in the Aβ+ group compared to the Aβ–group. Plasma Aβ₄₀ and Aβ₄₂ levels were not significantly different between Aβ–and Aβ+ groups, although a trend of higher plasma Aβ₄₀ was observed in the Aβ+ group. Additionally, plasma Aβ₄₂/Aβ₄₀ ratios along with the known AD risk factors, age and APOE ɛ4 status, resulted in Aβ+ participants being distinguished from Aβ–participants based on an area under the receiver operating characteristic curve shown to be 78%. Conclusion: Plasma Aβ ratios in this study are a potential biomarker for brain Aβ deposition and therefore, for preclinical AD. However, this method to measure plasma Aβ needs further development to increase the accuracy of this promising AD blood biomarker.]]> Fri 11 Nov 2022 18:51:47 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:33774 Fri 11 Jan 2019 14:26:39 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:37036 Fri 03 Dec 2021 10:32:41 AEDT ]]>